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Longevity & Biohacking

Evidence-based longevity supplements, devices, and protocols

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◈How We Evaluated This Category

✓What to Look For

•Clinical trials on longevity biomarkers (NAD+, telomeres, epigenetic age)
•Third-party testing for purity (heavy metals, microplastics)
•Dosages matching research protocols (Bryan Johnson Blueprint doses)
•Synergistic stacking (supplements that work together)
•Bioavailability optimization (liposomal, time-release, cofactors)

✗Red Flags to Avoid

•Proprietary blends hiding dosages
•Claims without human clinical trials
•Mega-doses exceeding safe upper limits
•Multi-level marketing supplement companies
•Anti-aging products with no biomarker evidence

📋Our Methodology

Products evaluated against Bryan Johnson's Blueprint protocol, clinical longevity research, and biomarker improvement data. Prioritized supplements with evidence of improving biological age markers.

🏅Key Certifications to Know

NSF Certified for Sport — Tested for 280+ banned substances, verified label accuracy

USP Verified — Independent verification of identity, strength, purity

GRAS Status — Generally Recognized As Safe by FDA

GMP Certified — Good Manufacturing Practice - quality production standards

blueprint supplements(26)

⏳01Gold Standard

11/12

Tru Niagen

Nicotinamide Riboside (NR)

$45($1.50/serving)

NAD+ precursor used to support cellular energy, DNA repair, and sirtuin activity.

blueprintlongevitynad+1

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⏳01Gold Standard

11/12

Blueprint

Essential Capsules

$55($1.83/serving)

Consolidates over 25 key nutrients including Vitamin D3, K2, Zinc, and Boron into one formula.

blueprintmultivitaminfoundational

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⏳01Gold Standard

11/12

NOW Foods

N-Acetyl-Cysteine (NAC)

$18($0.18/serving)

Precursor to glutathione, the body's master antioxidant; supports liver and lung health.

blueprintantioxidantglutathione

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⏳01Gold Standard

12/12

Life Extension

Taurine

$12($0.40/serving)

Amino acid that supports metabolic health, cardiovascular function, and longevity (based on recent primate/mouse studies).

blueprinttaurinemetabolism

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⏳01Gold Standard

12/12

Life Extension

Magnesium Malate

$15($0.15/serving)

Supports over 300 enzymatic reactions, muscle function, and energy production.

blueprintmagnesiumenergy

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⏳01Gold Standard

12/12

Life Extension

BioActive Complete B-Complex

$18($0.30/serving)

Provides methylated and active forms of B vitamins for methylation support and energy.

blueprintb-complexmethylation

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⏳01Gold Standard

12/12

Life Extension

Super K

$22($0.24/serving)

Directs calcium to bones and away from arteries to prevent calcification.

blueprintvitamin-kheart-health

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⏳01Gold Standard

11/12

Life Extension

Super Ubiquinol CoQ10

$32($0.53/serving)

Mitochondrial support and antioxidant protection for the heart.

blueprintcoq10mitochondria

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⏳01Gold Standard

12/12

Life Extension

Alpha Lipoic Acid (ALA)

$16($0.26/serving)

Universal antioxidant that regenerates other antioxidants and supports glucose metabolism.

blueprintalaantioxidant

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⏳01Gold Standard

11/12

Life Extension

DHEA

$12($0.12/serving)

Hormone precursor that declines with age; supports immune function and bone density.

blueprinthormonesdhea

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⏳01Gold Standard

11/12

Life Extension

Glucosamine Sulfate

$24($0.40/serving)

Supports joint health and has been associated with reduced all-cause mortality in large observational studies.

blueprintjointslongevity

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⏳01Gold Standard

12/12

Kyolic

Aged Garlic Extract

$20($0.33/serving)

Cardiovascular health, specifically reducing arterial plaque and improving blood pressure.

blueprintgarlicheart-health

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⏳01Gold Standard

11/12

Life Extension

Ginger

$14($0.23/serving)

Anti-inflammatory and digestive support.

blueprintgingerinflammation

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⏳01Gold Standard

11/12

Life Extension

Curcumin (BCM-95)

$30($0.50/serving)

Potent anti-inflammatory and antioxidant.

blueprintcurcumininflammation

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⏳01Gold Standard

12/12

Life Extension

Lutein & Zeaxanthin

$20($0.33/serving)

Eye health and protection against blue light/macular degeneration.

blueprinteye-healthlutein

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⏳01Gold Standard

11/12

Life Extension

Astaxanthin

$14($0.46/serving)

Powerful carotenoid antioxidant that supports skin health and mitochondrial function.

blueprintastaxanthinantioxidant

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⏳01Gold Standard

10/12

Life Extension

Spermidine

$26($0.86/serving)

Induces autophagy (cellular cleanup) and supports heart health.

blueprintautophagyspermidine

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⏳01Gold Standard

11/12

Life Extension

Fisetin

$12($0.40/serving)

Senolytic agent that helps clear out 'zombie' (senescent) cells.

blueprintsenolyticfisetin

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⏳01Gold Standard

11/12

Life Extension

Quercetin Phytosome

$20($0.33/serving)

Antioxidant and senolytic that works synergistically with other longevity compounds.

blueprintquercetinsenolytic

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⏳01Gold Standard

10/12

BrocElite

Sulforaphane

$45($1.50/serving)

Activates Nrf2 pathway for detoxification and DNA protection.

blueprintsulforaphanenrf2

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⏳01Gold Standard

12/12

Life Extension

Ashwagandha (KSM-66)

$12($0.20/serving)

Adaptogen for stress management and cortisol reduction.

blueprintadaptogenstress

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⏳01Gold Standard

12/12

Prescription

Metformin

$5($0.10/serving)

AMPK activator and glucose-lowering agent with significant longevity data.

blueprintmetforminprescription

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⏳01Gold Standard

12/12

Blueprint

Blueprint Creatine

$30($0.50/serving)

For cognitive function, muscle maintenance, and cellular energy.

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⏳02Excellent

11/12

Life Extension

Lithium Orotate (Micro-dose)

$10($0.10/serving)

Micro-dosing lithium is associated with neuroprotection and mood stability.

blueprintbrain-healthlithium

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⏳02Excellent

11/12

Life Extension

Hyaluronic Acid

$15($0.50/serving)

Supports skin hydration and joint lubrication.

blueprintskinjoints

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⏳03Good

11/12

Blueprint

Blueprint Amino Complex

$45($1.50/serving)

Essential amino acids to support muscle protein synthesis without the caloric load of whole protein.

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blueprint foods(18)

⏳01Gold Standard

11/12

Blueprint

Longevity Mix

$65($2.16/serving)

A comprehensive drink mix containing Creatine, Glucosamine, and various polyphenols.

blueprintcreatineakg

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⏳01Gold Standard

11/12

Blueprint

Blueprint Extra Virgin Olive Oil (Snake Oil)

$30($1.00/serving)

Bryan uses this as a primary source of healthy fats and polyphenols, specifically oleocanthal, for cardiovascular health and inflammation reduction.

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⏳01Gold Standard

11/12

Blueprint

Blueprint Cocoa Powder

$25($0.83/serving)

High-flavanol cocoa is used to support circulatory health, cognitive function, and skin health.

blueprintlongevityantioxidants+1

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⏳01Gold Standard

11/12

Blueprint

Blueprint Plant-Based Protein

$50($1.66/serving)

A clean, pea-based protein source used to maintain muscle mass while adhering to a vegan protocol.

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⏳01Gold Standard

10/12

Bragg

Organic Apple Cider Vinegar

$6($0.10/serving)

Used in the Super Veggie to improve insulin sensitivity and digestion.

blueprintsuper-veggiedigestion+1

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⏳01Gold Standard

10/12

Sun Chlorella

Sun Chlorella Powder

$35($1.16/serving)

Included in the 'Green Giant' beverage for spermidine, chlorophyll, and nucleic acids.

blueprintgreen-giantspermidine+1

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⏳01Gold Standard

11/12

Manitoba Harvest

Hemp Hearts

$12($0.25/serving)

A topping for the Super Veggie to provide Omega-3 and Omega-6 fatty acids and complete protein.

blueprintsuper-veggieomega-3+1

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⏳01Gold Standard

10/12

Terrasoul Superfoods

Raw Organic Macadamia Nuts

$18($1.20/serving)

Core ingredient in Nutty Pudding for monounsaturated fats and creamy texture.

blueprintnutty-puddinghealthy-fats

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⏳01Gold Standard

11/12

Blueprint

Nutty Pudding Mix

$60($2.00/serving)

A pre-mixed version of Bryan's famous Nutty Pudding to ensure exact ratios of walnuts, macadamias, and flax.

blueprintnutty-puddingmeal-replacement

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⏳01Gold Standard

10/12

Blueprint

Blueberry Nut Mix

$25($1.25/serving)

A snack or topping for Nutty Pudding containing high-antioxidant blueberries and walnuts.

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⏳02Excellent

12/12

Palouse Brand

Black Beluga Lentils

$15($0.30/serving)

The base of the 'Super Veggie' meal, providing fiber, plant protein, and anthocyanins.

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⏳02Excellent

9/12

POM Wonderful

100% Pomegranate Juice

$10($0.60/serving)

Used in Nutty Pudding for its high antioxidant content and potential to stimulate Urolithin A production.

blueprintnutty-puddingantioxidants+1

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⏳02Excellent

10/12

Frontier Co-op

Organic Ceylon Cinnamon

$15($0.05/serving)

Used in Nutty Pudding for flavor and blood sugar regulation.

blueprintnutty-puddingblood-sugar

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⏳03Good

9/12

Generic Organic

Organic Shiitake Mushrooms

$5($1.25/serving)

A key component of Super Veggie for immune support and vitamin D precursors.

blueprintsuper-veggieimmunity+1

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⏳03Good

10/12

Generic Organic

Organic Broccoli

$3($1.50/serving)

The primary volume component of Super Veggie, chosen for sulforaphane content.

blueprintsuper-veggiesulforaphane+1

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⏳03Good

9/12

Generic Organic

Organic Cauliflower

$4($1.00/serving)

Cruciferous vegetable in Super Veggie providing fiber and vitamin C.

blueprintsuper-veggiefiber+1

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⏳03Good

10/12

Generic Organic

Fresh Organic Ginger

$2($0.05/serving)

Added to Super Veggie for its anti-inflammatory and pro-kinetic (digestive) properties.

blueprintsuper-veggieinflammation+1

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⏳03Good

10/12

Generic Organic

Fresh Organic Garlic

$1($0.03/serving)

Used in Super Veggie for cardiovascular health and immune support via allicin.

blueprintsuper-veggieheart-health+1

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blueprint equipment(14)

⏳01Gold Standard

10/12

Eight Sleep

Pod 3 Cover

$2295(N/A)

Used to maintain optimal core body temperature throughout the night, which Bryan identifies as critical for maximizing Deep and REM sleep.

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⏳01Gold Standard

10/12

Whoop

Whoop 4.0

$30/mo(N/A)

Used as a secondary validation for recovery and to monitor cardiovascular strain during his daily 1-hour workouts.

blueprintlongevityfitness+1

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⏳01Gold Standard

10/12

Withings

Body Scan

$399(N/A)

Bryan uses this for segmental body composition (fat/muscle mass per limb) and to track Vascular Age via Pulse Wave Velocity.

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⏳01Gold Standard

10/12

TrueDark

Twilight Elite

$89(N/A)

To block the full spectrum of blue, green, and violet light in the evening to prevent melatonin suppression.

blueprintlongevitysleep+1

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⏳01Gold Standard

12/12

Polar

H10 Heart Rate Sensor

$90(N/A)

Bryan uses the H10 for the most accurate heart rate data during exercise, as chest straps outperform wrist sensors during movement.

blueprintlongevityfitness+1

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⏳01Gold Standard

12/12

Omron

Platinum Blood Pressure Monitor

$79(N/A)

Bryan targets a blood pressure of 110/70. Daily monitoring is essential to ensure his diet and supplements are maintaining this target.

blueprintlongevitycardio+1

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⏳01Gold Standard

10/12

Omnilux

Omnilux Contour Face

$395(N/A)

Specifically used for facial skin health to reduce fine lines, wrinkles, and pigmentation as part of his 'Project Baby Face'.

blueprintlongevityskin+1

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⏳01Gold Standard

12/12

Rogue Fitness

Echo Bike

$895(N/A)

Used for Bryan's high-intensity interval training (HIIT) to maximize VO2 max, which is a top predictor of longevity.

blueprintlongevityfitness+1

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⏳02Excellent

11/12

Oura

Oura Ring Gen 3

$299(N/A)

Bryan uses the Oura Ring as his primary device for tracking sleep stages, resting heart rate, and heart rate variability (HRV). It is essential for his data-driven approach to recovery.

blueprintlongevitysleep+1

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⏳02Excellent

12/12

Abbott

FreeStyle Libre 3

$75($37.50/sensor)

Continuous Glucose Monitoring (CGM) allows Bryan to see real-time blood sugar responses to every food in the Blueprint protocol.

blueprintlongevitymetabolism+1

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⏳02Excellent

9/12

Joovv

Joovv Solo 3.0

$699(N/A)

Red and Near-Infrared (NIR) light therapy for mitochondrial health, skin rejuvenation, and reducing inflammation.

blueprintlongevityred-light+1

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⏳02Excellent

9/12

Pulsetto

$269(N/A)

Used for non-invasive Vagus Nerve Stimulation (nVNS) to increase HRV and induce a state of parasympathetic calm.

blueprintlongevityHRV+1

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⏳02Excellent

11/12

Philips Sonicare

DiamondClean 9000

$199(N/A)

Oral health is a pillar of Blueprint due to the link between gum disease and systemic inflammation/heart disease.

blueprintlongevityoral-health

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⏳03Good

8/12

Molekule

Air Pro

$1014(N/A)

Bryan maintains strict air quality standards (PM2.5 < 1) in his home to reduce systemic inflammation from pollutants.

blueprintlongevityenvironment+1

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nad boosters(4)

⏳01Gold Standard

11/12

Thorne

Thorne is the most trusted name in clinical-grade supplements, and NiaCel 400 uses Nicotinamide Riboside Malate for superior stability and absorption. The NSF Certified for Sport designation ensures it is free from contaminants and accurately labeled.

nrnicotinamide-ribosidensf-certified+1

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⏳01Gold Standard

10/12

Tru Niagen

Tru Niagen 300mg

$47.00($1.56/serving)

Tru Niagen is the flagship product for Nicotinamide Riboside (NR), backed by the company (ChromaDex) that holds the primary patents and has funded the majority of NR human trials. It is the most scientifically 'proven' NAD+ booster on the market.

nrniagenpatented+1

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⏳01Gold Standard

10/12

ProHealth Longevity

NMN Pro 1000

$69.95($1.16/serving)

ProHealth uses Uthever NMN, which is widely considered the highest quality branded NMN ingredient. They are one of the few companies that perform triple-testing on every batch to ensure zero degradation.

nmnutheverpharmaceutical-grade+1

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⏳02Excellent

12/12

Renue By Science

Pure NMN Powder

$44.95($0.45/gram)

Renue By Science sets the industry standard for transparency by providing batch-specific COAs for purity, heavy metals, and stability. Their pure powder form eliminates all fillers and offers the most cost-effective way to achieve high-dose NMN supplementation.

nmnpowderpure+1

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senolytics(4)

⏳01Gold Standard

11/12

Neurohacker Collective

Qualia Senolytic

$79.00($39.50/serving)

This is the most comprehensive senolytic formula on the market, utilizing a 'hit-and-run' dosing strategy (2 days a month) modeled after the Mayo Clinic protocols. It combines nine different senolytic compounds including Fisetin, Quercetin, and Luteolin in high-potency forms.

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⏳01Gold Standard

11/12

Life Extension

Senolytic Activator

$19.50($1.62/serving)

Life Extension offers the best value-to-science ratio by using Bio-Fisetin, which is formulated with galactomannans from fenugreek seeds to increase bioavailability by 25 times over standard fisetin.

valuebio-fisetinapigenin+1

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⏳01Gold Standard

10/12

Renue by Science

LIPO Fisetin - Powdered Liposomal

$44.95($0.50/capsule)

Renue by Science specializes in liposomal delivery, which is arguably the most effective way to deliver hydrophobic senolytics like Fisetin directly into the bloodstream while bypassing first-pass metabolism.

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⏳03Good

10/12

Thorne

Quercetin Phytosome

$36.00($0.60/capsule)

Thorne is the gold standard for clinical purity. Their Quercetin Phytosome uses the Indena Quercefit delivery system, which is proven to be up to 20 times more bioavailable than standard quercetin.

quercetinpurebioavailable+1

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autophagy(4)

⏳01Gold Standard

11/12

Longevity Labs

Spermidine Life Standard

$99.00($1.65/serving)

This is the 'gold standard' for spermidine, derived from non-GMO European wheat germ. It is the specific formulation used in the SmartAge human clinical trials, proving its ability to trigger autophagy and improve cognitive markers.

spermidinewheat germcellular renewal+1

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⏳01Gold Standard

10/12

Life Extension

Senolytic Activator

$19.50($1.62/serving)

This formula combines Fisetin, Quercetin, and Apigenin to target senescent cells and induce autophagy. It uses a specialized galactomannan fiber to increase the bioavailability of Fisetin by up to 25 times.

senolyticfisetinquercetin+1

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⏳01Gold Standard

11/12

DoNotAge

Pure Spermidine

$60.00($1.00/serving)

For those seeking the highest dose of pure spermidine rather than a food extract, DoNotAge offers 8mg of Spermidine Trihydrochloride per capsule. This is significantly higher than most wheat germ extracts.

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⏳03Good

11/12

Timeline Nutrition

Mitopure Softgels

$125.00($3.33/serving)

Mitopure is a proprietary, highly pure form of Urolithin A, which specifically triggers mitophagy (the autophagy of damaged mitochondria). It is the only Urolithin A supplement with significant human clinical backing for muscle strength and cellular energy.

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cgm monitors(3)

⏳01Gold Standard

12/12

Dexcom

Stelo Glucose Biosensor

$99($3.30/day)

Stelo is the first FDA-cleared CGM specifically designed for non-insulin users, making it the premier choice for longevity enthusiasts. It utilizes the same high-accuracy sensor technology as the medical-grade G7 but optimized for metabolic health tracking without requiring a prescription.

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⏳01Gold Standard

11/12

Abbott

FreeStyle Libre 3

$75-$150($2.68/day)

The Libre 3 is the smallest, thinnest CGM on the market (the size of two stacked pennies), offering the highest clinical accuracy (7.9% MARD) available in a consumer-ready device. It provides minute-by-minute readings directly to a smartphone without the need for manual scanning.

high-accuracysmall-form-factorprescription-required

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⏳01Gold Standard

11/12

Dexcom

Dexcom G7

$170-$200($5.66/day)

The Dexcom G7 is the gold standard for ecosystem integration, allowing users to see their glucose data on Apple Watch, Garmin, and various longevity platforms simultaneously. It features a 30-minute warm-up time, the fastest in the industry.

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red light therapy(3)

⏳01Gold Standard

12/12

Mito Red Light

MitoPRO 300

$379($379/unit)

The MitoPRO 300 is the gold standard for desktop panels, offering a unique four-wavelength blend (630nm, 660nm, 830nm, 850nm) that targets both surface skin health and deeper tissue recovery. It features high irradiance with low EMF and zero flicker, backed by comprehensive third-party testing.

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⏳01Gold Standard

11/12

PlatinumLED Therapy Lights

BIOMAX 300

$459($459/unit)

The BIOMAX series is arguably the most powerful panel on the market, utilizing a patent-pending 7-band spectrum that includes 480nm (blue light) and 1060nm (near-infrared) for a comprehensive therapeutic effect. It is the choice for users seeking maximum irradiance and spectral diversity.

high-powermulti-bandneuro-recovery+1

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⏳02Excellent

9/12

Hooga

HGPRO300 High Intensity Panel

$159($159/unit)

Hooga is the best entry-point for red light therapy, providing a reliable, high-irradiance device at a fraction of the cost of premium brands. It focuses on the two most clinically studied wavelengths: 660nm and 850nm.

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cold exposure(3)

⏳01Gold Standard

11/12

Plunge

The Plunge All-In

$4,990($4,990/unit)

The Plunge All-In is the industry standard for home cold immersion, featuring a powerful 1HP cooling system and a fully integrated filtration unit. It is one of the few units on the market that is UL-certified for safety, ensuring electrical components are safe for water immersion environments.

cold plungerecoverylongevity+1

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⏳01Gold Standard

10/12

Morozko Forge

Filtered Forge

$12,850($12,850/unit)

The Morozko Forge is the only cold plunge on the market that actually produces its own ice, allowing for a true 32.1°F experience without ever needing to buy bags of ice. It is the gold standard for 'coldest' possible exposure.

ice makerultra-coldpremium+1

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⏳02Excellent

11/12

Ice Barrel

Ice Barrel 500

$1,499($1,499/unit)

The Ice Barrel 500 offers a superior upright, fully insulated design that allows for a more natural 'fetal' position, which research suggests can improve the psychological 'grit' aspect of cold exposure. It is highly durable and features built-in steps and a seat.

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sauna(4)

⏳01Gold Standard

11/12

Clearlight

Sanctuary 2 Full Spectrum Infrared Sauna

$6,299(N/A)

Clearlight is the gold standard for infrared longevity due to its patented True Wave heaters that provide near, mid, and far-infrared while maintaining the lowest EMF and ELF levels in the industry. It features medical-grade construction with VOC-tested wood and non-toxic glues, ensuring no off-gassing during high-heat sessions.

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⏳01Gold Standard

11/12

Sunlighten

mPulse Aspire

$7,500-$9,000(N/A)

Sunlighten mPulse is the only smart sauna with 3-in-1 SoloCarbon heaters that can be programmed to specific wavelengths for anti-aging, heart health, or recovery. Their technology is backed by specific clinical trials showing significant blood pressure reduction and core temperature increase.

smart-sauna3-in-1-infraredanti-aging+1

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⏳01Gold Standard

10/12

Finnleo

Northview Series Traditional Sauna

$8,500+(N/A)

For those following the Finnish longevity protocols (80-100°C), Finnleo provides the most authentic and high-quality traditional steam experience. Traditional saunas have the strongest long-term data regarding Heat Shock Protein (HSP) activation and dementia prevention.

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⏳02Excellent

9/12

HigherDOSE

Infrared Sauna Blanket

$699(N/A)

The HigherDOSE blanket is the best entry-point for longevity enthusiasts who lack the space or budget for a full cabin. It uses far-infrared heat with low-EMF carbon heaters and incorporates layers of amethyst, tourmaline, and charcoal to enhance the detox experience.

portablesauna-blanketbudget-friendly+1

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sleep trackers(4)

⏳01Gold Standard

11/12

Oura

Oura Ring Gen3

$299-$449($299/unit)

The Oura Ring remains the gold standard for consumer sleep tracking due to its non-intrusive form factor and high-fidelity PPG sensors. It is the most utilized wearable in clinical sleep research, offering laboratory-level correlation for heart rate and respiratory metrics.

wearablebiometricsrecovery+1

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⏳01Gold Standard

11/12

Withings

Withings Sleep Analyzer

$129.95($129.95/unit)

This is the best 'invisible' tracker that requires no wearable device. It uses ballistocardiography via a pneumatic sensor to detect heart rate, respiration, and movement with medical-grade precision.

under-mattressnon-wearablesleep-apnea+1

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⏳01Gold Standard

12/12

Apple

Apple Watch Series 9

$399($399/unit)

The Apple Watch Series 9 features the most accurate heart rate sensor in the consumer market, outperforming Oura and Whoop in several independent validation tests. Its sleep stage algorithm is highly refined and integrates with a massive health ecosystem.

smartwatchheart-healthaccurate-hrv+1

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⏳02Excellent

9/12

Eight Sleep

Eight Sleep Pod 4

$2,549-$4,000($2,549/unit)

The Eight Sleep Pod 4 is the only device that both tracks sleep and actively improves it through dynamic temperature regulation. It is a cornerstone of the 'Blueprint' longevity protocol for maximizing deep sleep.

temperature-controlactive-coolingblueprint+1

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