Gut Health

24 clinically-studied strains + prebiotic. 53.6 billion AFU (measured at expiration, not manufacture). Shelf-stable capsule-in-capsule technology.

Seed sets the industry standard with a 24-strain broad-spectrum formulation and a patented 'ViaCap' delivery system that ensures bacteria survive stomach acid. Their commitment to strain-specific clinical data and rigorous testing for 400+ allergens and pesticides is unmatched in the consumer space.

Visbiome contains the 'De Simone Formulation,' one of the most heavily researched probiotic blends in the world with over 70 clinical trials. It is a medical-grade probiotic designed for significant gut dysbiosis and IBS management.

Culturelle uses 100% Lactobacillus rhamnosus GG (LGG), which is the most clinically studied probiotic strain in the world. It is one of the few brands that is USP Verified, ensuring the product actually contains what it claims through the end of its shelf life.

Thorne's FloraSport 20 is specifically formulated for athletes and those with high-activity lifestyles. It is NSF Certified for Sport, which is a rare and vital certification for probiotics to ensure no banned substances or contaminants are present.

Thorne Prebiotic + stands out for its use of PreticX (XOS), a clinically validated prebiotic that works at much lower doses than traditional fibers, significantly reducing the risk of gas and bloating. It also includes green tea and pomegranate extracts to support the growth of Akkermansia, a 'keystone' gut bacteria linked to metabolic health.

HMOs are the most advanced class of prebiotics, originally found in human milk but now bio-identical and produced for adults. PureHMO is exceptionally targeted, feeding beneficial Bifidobacteria and supporting the gut barrier while inhibiting pathogens, making it superior for immune-gut health.

MegaPre is a 'precision' prebiotic designed to increase microbial diversity by feeding keystone bacteria like Akkermansia muciniphila, Faecalibacterium prausnitzii, and Bifidobacteria. It uses a unique blend of non-digestible oligosaccharides that are clinically shown to avoid feeding dysbiotic (harmful) bacteria.

This is the best value option for those looking for a clean, organic, food-based prebiotic. It uses Acacia fiber, which is known to be much gentler on the stomach than Inulin, and provides a solid 5g of prebiotic fiber per serving at a very accessible price point.

100% grass-fed, 20+ hour simmer, 10g protein/serving. Gels when refrigerated (indicates high gelatin). No MSG or additives.

Bonafide Provisions sets the standard by using a traditional 24-hour slow-simmer process and freezing the product immediately to preserve micronutrients and gelatin integrity without UHT processing. It uses strictly organic, grass-fed bones and triple-filtered water with no added 'natural flavors' or yeast extracts.

Kettle & Fire is the gold standard for shelf-stable broth, utilizing a long 20+ hour simmer and high-quality grass-fed bones. Their packaging is BPA-free and they are one of the few brands that consistently publishes information regarding their heavy metal testing.

Fond distinguishes itself through glass-jar packaging (eliminating plastic/TetraPak leaching) and a focus on regenerative agriculture. Their 'Liquid Gold' flavor specifically includes turmeric and black pepper to enhance the anti-inflammatory benefits for gut health.